Pharmacology Analysis

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Pharmacology Analysis nursing essay assignment help

Pharmacology Analysis nursing essay assignment

  1. What is Rheumatoid arthritis? – pathology, why it is invaded – expand
  2. What can you tell us about Th1 + TH17 immune responses?
  3. Why are macrophages/monocytes important in Rheumatoid arthritis?
  4. What growth stimuli activate MAPK pathways. What receptors are involved? – by what mechanism
  5. What stress stimuli are important in Rheumatoid arthritis?

Does ROS play a role and how would this influence macrophage/monocyte function?

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  1. How does this impact on macrophage activation and phenotype?
  2. How many macrophage phenotypes are there?
  3. A figure illustrating where drugs act in molecular pathways during Rheumatoid arthritis.
  4. What are glycosaminoglycans?
  5. How are sulphated disaccharides formed in vivo? Is heparinize-I unregulated during inflammation?
  6. What is the major sulphated disaccharide formed in joints? Is this found elsewhere in other inflammation conditions?
  7. Can you expand on the bell shaped response curve and what is the impact at high concentration of sulphated disaccharide and how does it propagate these effects?
  8. What are the receptors for these sulphated disaccharides? How does sulphation affect their binding properties?
  9. Have other groups demonstrated the anti-inflammatory properties of sulphated disaccharides?
  10. Why focus on P2, on macrophage and not neutrophil.

 

  1. Introduction needs to be a lot more detailed and expanded with evidence of wider literature search.
  2. include RA pathology in depth
  3. elaborate more on macrophage subsets
  4. macrophage polarization – is there any literature to support the divergence/polarization
  5. why particularly p38 and ERK1/2 and is there any relevance for these to RA
  6. anti-rheumatic drugs – should include a figure explaining how the available treatments works and elaborate on this section.
  7. What happens to 40% of the non-responder patients – look for some evidence.
  8. Sulphated disaccharides – chemistry (sulphur negative charge)
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